Seeking an Associate Scientist III for a 4 month assignment in Cambridge, MA.
Job Description: Scientist I, Translational Sciences
The Development Biomarkers and Bioanalytical Sciences group is seeking a highly motivated scientist to join a dynamic team that develops and executes bioanalytical and biomarker strategies for multiple programs across therapeutic areas.
Responsibilities include leading scientific research to identify, evaluate, and characterize relevant fluid biomarkers that will provide useful pharmacodynamic and efficacy endpoints in preclinical and clinical settings as well as development, validation and oversight of clinical PK and immunogenicity assays. The successful candidate will be capable of multitasking, setting goals, priorities, and planning timelines. Effective communication and collaboration are crucial. Ability to think critically and a commitment to learning are essential.- Develop and implement bioanalytical assays PK and immunogenicity to support development of large molecule and ASO assets- Develop biomarker assays for multiple programs across different therapeutic areas and lead clinical execution thereof- Provide oversight of PK and immunogenicity assay development, validation and interpretation of in-study immunogenicity data for multiple programs from preclinical through post-marketing phases- Oversee outsourced biomarker and bioanalytical assays at contract research laboratories- Prepare, review and deliver scientific presentations for internal/external audiences and author related manuscripts- Evaluate new assay/platform capabilities in house to support bioanalytical and biomarker analysis and provide technical expertise across platforms e.g. ELISA, qPCR, ISH, IHC, NGS, imaging, flow cytometry - Mentor and matrix-manage technical staff
Qualifications: Strong verbal and written communication skills; ability to deliver clear, concise presentations tailored to different audiences; Must be a highly flexible, results oriented, independent self-starter who enjoys working in a fast-paced dynamic environment. Ability to quickly absorb new information and develop an understanding of the relevant biology, pathway, MOA, disease indication s and develop sound scientific strategies; Strong desire to learn drug discovery development, from research through to post-marketing; Expertise with ligand binding and cell-based assays, utilizing a variety of technology platforms;Expertise in cellular and biochemical science including molecular biology and protein biochemistry techniques e.g. real-time PCR, DNA cloning, protein purification, Western blotting, immunoprecipitation, enzymatic assays .Experience managing scientific collaborations and/or outsourced work at contract research organizations is a plus
Education:PhD with at least 1-3 years relevant postdoctoral or industry experience although PhD is not required.
For immediate consideration please call 732-246-0215 or email to [Click Here to Email Your Resumé]
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