The candidate will be responsible for the analysis and characterization of cell and gene therapy products in early phase clinical development. This will involve various tasks including maintenance of cell lines, purification techniques including affinity/IEX chromatography, and cell-based assays to assess biological activity. It is expected the incumbent should have an understanding of virus titration assays (qPCR/ddPCR), silverstain/western blotting, DLS/DSF, ELISA, and confocal imaging. A strong background in molecular and cellular biology is required and CRISPR gene editing is required.
- Preferably 3+ years of experience working as a scientist in an academic, research, laboratory setting or biotech/pharma company
- Candidate should be knowledgeable in engineering AAV vectors
- Experience in mammalian cell culture and routine biological assays and data interpretation is required.
- Experience interpreting and presenting data to internal stakeholders
- Strong critical, scientific, and strategic thinking skills allowing individual to work independently with minimal supervision.
- Strong communication (verbal and written) skills
- Demonstrated ability to work collaboratively in cross-functional teams
Experience with documentation and reporting of results using electronic lab notebooks is a must.
The Associate Scientist in exploratory biology will assist with the development of Gene Therapy platform. The incumbent should be a highly motivated individual who demonstrates strong interpersonal skills, is accountable for outcomes and has a willingness to take on increasing levels of responsibility. As a member of the Exploratory Biology department, the candidate will contribute to research efforts related to the 1) production and purification of AAV, 2) the optimization of nucleic-acid delivery platforms and 3) the design of AAV as a vector for in vivo gene editing. The scientist will subsequently characterize gene delivery results and the functionality of cellular products via an array of biological assays.